[No authors listed]
Heat shock proteins are involved in cellular repair and protective mechanisms that counter characteristic features of neurodegenerative diseases such as protein misfolding and aggregation. The (Hsp70) multigene family includes the widely studied (Hsp70-1) and the little studied (Hsp70B') which is present in the human genome and not in mouse and rat. The effect of knockdown of Hduanyu18426 and Hduanyu18421A expression was examined in relation to the ability of differentiated human SH-SY5Y neuronal cells to tolerate thermal stress. Low dose co-application of celastrol and arimoclomol, which induces Hsps, enhanced the ability of differentiated neurons to survive heat shock. Small interfering RNA (siRNA) knockdown of Hduanyu18426 and Hduanyu18421A resulted in loss of the protective effect of co-application of celastrol/arimoclomol. More pronounced effects on neuronal viability were apparent at 44 °C heat shock compared to 43 °C. siRNA knockdown suggests that Hduanyu18426 and Hduanyu18421A contribute to protection of differentiated human neuronal cells from cellular stress.
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