[No authors listed]
Colorectal cancer (CRC) is the third most common type of diagnosed cancer and the fourth leading cause of cancerâassociated mortalities worldwide. Increasing studies have demonstrated that the deregulation of microRNAs (miRNAs or miRs) is associated with the occurrence and development of multiple types of human cancer, including CRC. miRâ329 has been identified to be downregulated in various types of cancer; however, its expression pattern, functions and mechanisms in CRC remain unclear. The present study demonstrated that miRâ329 was lowly expressed in CRC tissue samples and cell lines. Low expression of miRâ329 was correlated with tumorânodeâmetastasis stage and lymph node metastasis in patients with CRC. In vitro experiments revealed that resumption expression of miRâ329 suppressed cell proliferation and invasion in CRC. Furthermore, the results of the present study indicated that miRâ329 targets transforming growth factorâβ1 (TGFâβ1) directly in vitro. TGFâβ1 was demonstrated to be upregulated in CRC tissue samples and inversely correlated with miRâ329 expression. Upregulation of TGFâβ1 was able to partially counteract the antitumor roles of miRâ329 on CRC cell proliferation and invasion. The results of the current study revealed that miRâ329 suppresses CRC cell proliferation and invasion through targeting TGFâβ1, thus suggesting that targeting miRâ329/TGFâβ1 may provide a novel effective therapeutic approach for the treatment of patients with CRC.
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