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Expression of iNOS, COX-2 and VEGF in canine mammary tumours and non-neoplastic mammary glands: Association with clinicopathological features and tumour grade.

Acta Vet. Hung.2017 Sep;65(3):382-393. doi:10.1556/004.2017.036
Elvan Anadol 1 , Atiye Seda Yar Saglam 2 , Nilgun Gultiken 3 , Kubra Karakas 4 , Eray Alcigir 5 , Hasan Alkan 6 , Halit Kanca 4
Elvan Anadol 1 , Atiye Seda Yar Saglam 2 , Nilgun Gultiken 3 , Kubra Karakas 4 , Eray Alcigir 5 , Hasan Alkan 6 , Halit Kanca 4
+ et al

[No authors listed]

Author information
  • 1 1 Gazi University Laboratory, Animal Breeding and Experimental Research Centre, Faculty of Medicine, Gazi University , Besevler, Ankara , Turkey.
  • 2 2 Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University , Besevler, Ankara , Turkey.
  • 3 3 Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Ondokuz Mayis University , Kurupelit, Samsun , Turkey.
  • 4 4 Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Ankara University , Diskapi, Ankara , Turkey.
  • 5 5 Department of Pathology, Faculty of Veterinary Medicine, Ankara University , Diskapi, Ankara , Turkey.
  • 6 6 Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Selcuk University , Konya , Turkey.

摘要

The aim of the present study was to investigate the relationship between the expression of iNOS, COX-2 and VEGF mRNA levels and malignancy degree in canine malignant mammary tumours. Thirty-five bitches presented with the complaint of mammary masses, aged 6-10 years and representing different breeds, were used. The expressions of iNOS, COX-2 and VEGF mRNA levels were significantly higher in both benign and malignant tumours than in the adjacent nonneoplastic mammary glands (P < 0.05). The iNOS, COX-2 and VEGF mRNA expression levels of grade 2 tumours were higher than those of grade 1 tumours; however, the highest expression levels were detected in grade 3 tumours. Thus, increased iNOS, COX-2 and VEGF gene mRNA levels were found to be related with the histological grade of malignancy in dogs with mammary tumours.

KEYWORDS: COX-2, Canine mammary tumour, VEGF, gene expression, iNOS

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