Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression.

J. Immunol.2017 Nov 01;199(9):3261-3269. Epub 2017 Sep 27

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摘要

-gallate (EGCG) increases the expression of Toll interacting protein, a strong inhibitor of TLR4 signaling, by suppressing the expression of E74-like ETS transcription factor 1 (Elf-1). A mechanistic study revealed that EGCG suppressed Elf-1 expression via protein phosphatase 2A/cyclic GMP (cGMP)-dependent mechanisms. We also confirmed that orally administered EGCG and a cGMP inducer upregulated Toll interacting protein expression, increased intracellular levels of cGMP in macrophages, and suppressed Elf-1 expression. These data support EGCG and a cGMP inducer as potential candidate suppressors of TLR4 signaling.

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Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression.

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