MicroRNA-195 Activates Hepatic Stellate Cells In Vitro by Targeting Smad7.

Biomed Res Int. 2017;2017:1945631. doi:10.1155/2017/1945631. Epub 2017 Aug 27

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BACKGROUND AND AIM:1/Smad pathway contributes to the activation of hepatic stellate cells (HSCs). MicroRNA-195 has been shown to regulate the activation of HSCs. The aim of this study was to investigate the role of miRNA-195 in HSCs activation. METHODS:-SMA in HSC-T6 transfected, respectively, with miR-195 mimic, inhibitor, or control were measured by qRT-PCR. The protein expression of Smad7 was detected by Western blot analysis. RESULTS: < 0.05). CONCLUSION:Collectively, we demonstrated that miRNA-195 activated HSCs by targeting Smad7.

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MicroRNA-195 Activates Hepatic Stellate Cells In Vitro by Targeting Smad7.

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