LncRNA TRERNA1 Function as an Enhancer of SNAI1 Promotes Gastric Cancer Metastasis by Regulating Epithelial-Mesenchymal Transition.

Long noncoding RNA (lncRNA) has been implicated in cancer, but little is known about the role of lncRNAs as regulators of tumor metastasis. In the present study, we demonstrate that lncRNA acts like an enhancer of SNAI1 to promote cell invasion and migration and to contribute to metastasis of gastric cancer (GC). Tduanyu1795NA1 is significantly unregulated in GCs and GC cell lines. Increased Tduanyu1795NA1 is positively correlated with lymph node metastasis of GCs. RNA immunoprecipitation (RIP) and chromatin immunoprecipitation (ChIP) assays revealed that Tduanyu1795NA1 functions as a scaffold to recruit EZH2 to epigenetically silence epithelial-mesenchymal transition marker CDH1 by H3K27me3 of its promoter region. Tduanyu1795NA1 knockdown markedly reduced GC cell migration, invasion, tumorigenicity, and metastasis. Depletion of Tduanyu1795NA1 reduced cell metastasis of GCs in vivo. Taken together, our findings indicated that Tduanyu1795NA1 serves as a critical effector in GC progression by regulating CDH1 at the transcription level. It is implied that is a new potential target for GC therapy.

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