例如:"lncRNA", "apoptosis", "WRKY"

Drosophila MIC60/mitofilin conducts dual roles in mitochondrial motility and crista structure.

Mol. Biol. Cell. 2017 Nov 15;28(24):3471-3479. Epub 2017 Sep 13
Pei-I Tsai 1 , Amanda M Papakyrikos 2 , Chung-Han Hsieh 1 , Xinnan Wang 3
Pei-I Tsai 1 , Amanda M Papakyrikos 2 , Chung-Han Hsieh 1 , Xinnan Wang 3

[No authors listed]

Author information
  • 1 Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305.
  • 2 Graduate Program in Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.
  • 3 Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305 xinnanw@stanford.edu.

摘要


MIC60/mitofilin constitutes a hetero-oligomeric complex on the inner mitochondrial membranes to maintain crista structure. However, little is known about its physiological functions. Here, by characterizing Drosophila MIC60 mutants, we define its roles in vivo. We discover that MIC60 performs dual functions to maintain mitochondrial homeostasis. In addition to its canonical role in crista membrane structure, MIC60 regulates mitochondrial motility, likely by influencing protein levels of the outer mitochondrial membrane protein Miro that anchors mitochondria to the microtubule motors. Loss of MIC60 causes loss of Miro and mitochondrial arrest. At a cellular level, loss of MIC60 disrupts synaptic structure and function at the neuromuscular junctions. The dual roles of MIC60 in both mitochondrial crista structure and motility position it as a crucial player for cellular integrity and survival.