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CD34 Differentially Regulates Contractile and Noncontractile Elements of Airway Reactivity.

Am. J. Respir. Cell Mol. Biol.2018 Jan;58(1):79-88. doi:10.1165/rcmb.2017-0008OC
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摘要


mice 24 hours after the last exposure to HDM compared with naive controls. This was reversed when airway reactivity was measured 1 week after the last HDM exposure. Additionally, mast cell degranulation and mucus production were altered in the absence of CD34 expression. Importantly, simultaneous expression of CD34 on cells originating from the hematopoietic compartment and the microenvironment was needed for expression of this phenotype. These results provide evidence that CD34 is required for AHR and airway reactivity maintenance in the early days after an inflammatory episode in asthma.

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