Reversal of hyperactive Wnt signaling-dependent adipocyte defects by peptide boronic acids.
Proc. Natl. Acad. Sci. U.S.A.2017 Sep 05;114(36):E7469-E7478. Epub 2017 Aug 21
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摘要
mutants by identifying bortezomib and additional peptide boronic acids. We show that the suppressive effect of peptide boronic acids on hyperactive Wnt signaling is dependent on α-catenin; the rescue effect is completely abolished with the depletion of α-catenin in adipocytes. These results indicate that rather than targeting the canonical Wnt signaling pathway directly, pharmacologic modulation of β-catenin activity through α-catenin is a potentially attractive approach to attenuating Wnt signaling in vivo.
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原始数据
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文献解读
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