Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions.

Sci Rep. 2017 Aug 10;7(1):7786

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mice also exhibited significantly reduced renal Klotho expression under phosphate overload conditions, and aging phenotypes in these mice were rescued by Klotho overexpression, a low vitamin D diet or vitamin D receptor knockout. These findings indicate that Enpp1 plays a crucial role in regulating aging via Klotho expression under phosphate overload conditions.

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Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions.

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