mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation.

Science. 2017 Sep 08;357(6355):1014-1021. Epub 2017 Aug 10

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17 polarity. The mechanism for this change was independent of translational control but dependent on inflammatory DCs, which produced interleukin-23 and increased fatty acid oxidation. mTOR therefore mediates metabolic adaptation of APCs in distinct tissues, influencing the immunological character of allergic inflammation.

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mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation.

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