coordination controls sonic hedgehog structure and its Scube2-regulated release.
J. Cell. Sci.2017 Oct 01;130(19):3261-3271. Epub 2017 Aug 04
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摘要
occupancy of Shh ectodomains, unveiling a new mode of shedding regulation at the substrate level. Importantly, Scube2 uncouples processing of Shh peptides from their lipid-mediated juxtamembrane positioning, and thereby explains the long-standing conundrum that N-terminally unlipidated Shh shows patterning activity in Scube2-expressing vertebrates, but not in invertebrates that lack Scube orthologs.
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基因功能
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原始数据
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文献解读
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