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Increased expression of PD-L1 and PD-L2 in dermal fibroblasts from alopecia areata mice.

J. Cell. Physiol.2018 Mar;233(3):2590-2601. doi:10.1002/jcp.26134. Epub 2017 Sep 04
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摘要

T cells. We also found that the expression of PD-L1 and PD-L2 was co-localized with type 1 pro-collagen, CD90 and vimentin, which are biomarkers for dermal fibroblasts. Further studies revealed that releasable factors from activated, but not inactivated, lymphocytes significantly increase the expressions of both PD-L1 and PD-L2 in cultured dermal fibroblasts. In conclusion, our findings suggest that the expression of PD-L1 and PD-L2 in dermal fibroblasts is up-regulated by activated T cells in AA-affected skin, and as such, these regulatory molecules may not exert a negative control of the immune activation seen in AA lesions.

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