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Polycomb-mediated chromatin loops revealed by a subkilobase-resolution chromatin interaction map.

Proc. Natl. Acad. Sci. U.S.A.2017 Aug 15;114(33):8764-8769. Epub 2017 Aug 01
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摘要

were found most often in association with the polycomb group (PcG) protein Polycomb (Pc), a subunit of polycomb repressive complex 1 (PRC1). Loops were frequently located within domains of PcG-repressed chromatin. Promoters located at PRC1 loop anchors regulate some of the most important developmental genes and are less likely to be expressed than those not at PRC1 loop anchors. Although DNA looping has most commonly been associated with enhancer-promoter communication, our results indicate that loops are also associated with gene repression.

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