expression in mouse spermatids.
J. Cell. Sci.2017 Sep 01;130(17):2854-2866. Epub 2017 Jul 25
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摘要
mice display premature expression of the transition protein TNP2 and the protamine PRM2 due to translational derepression. The aberrant localisation of these key sperm-specific chromatin components, together with the persistence of somatic histones, results in abnormal spermatid elongation, failure to complete spermatid differentiation and azoospermia in these mice. Our study thus identifies IP6K1 as an indispensable factor in the temporal regulation of male germ cell differentiation.This article has an associated First Person interview with the first author of the paper.
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基因功能
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原始数据
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文献解读
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