Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway.

Cell Death Dis. 2017 Jul 20;8(7):e2942

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phenotype mimics aspects of Shh pathway deficiency, suggesting an intrinsic requirement for Maml1 in cerebellum development. The present study shows a new role for Maml1 as a component of Shh signaling, which plays a crucial role in both development and tumorigenesis.

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Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway.

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