例如："lncRNA", "apoptosis", "WRKY"

Genetic risk between the CACNA1I gene and schizophrenia in Chinese Uygur population.

Hereditas. 2017 Jul 17;155:5. eCollection 2018
Wei Xu 1 , Yahui Liu 1 , Jianhua Chen 2 , Qingli Guo 1 , Ke Liu 1 , Zujia Wen 1 , Zhaowei Zhou 1 , Zhijian Song 1 , Juan Zhou 1 , Lin He 1 , Qizhong Yi 3 , Yongyong Shi 1
Wei Xu 1 , Yahui Liu 1 , Jianhua Chen 2 , Qingli Guo 1 , Ke Liu 1 , Zujia Wen 1 , Zhaowei Zhou 1 , Zhijian Song 1 , Juan Zhou 1 , Lin He 1 , Qizhong Yi 3 , Yongyong Shi 1
+ et al

[No authors listed]

Author information
  • 1 Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University, Shanghai, 200030 People's Republic of China.
  • 2 Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030 People's Republic of China.
  • 3 Psychological Medicine Center, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, Xinjiang, 830054 China.

摘要

BACKGROUND:Schizophrenia (SCZ) is a common mental disorder with high heritability, and genetic factors play a major role in the pathogenesis. Recent researches indicated that the CACNA1I involved in calcium channels probably affect the potential pathogenesis of SCZ. RESULTS:In this study, we attempted to investigate whether the CACNA1I gene contributes the risk to SCZ in the Uighur Chinese population, and performed a case-control study involving 985 patient samples and 1218 normal controls to analyze nine SNPs within the CACNA1I gene. Among these sites, six SNPs were significantly associated with SCZ in the allele distribution: rs132575 (adjusted P  = 0.039, OR = 1.159), rs713860 (adjusted P  = 0.039, OR = 0.792), rs738168 (adjusted P  = 0.039, OR = 0.785), rs136805 (adjusted P  = 0.014, OR = 1.212), rs5757760 (adjusted P  = 0.042, OR = 0.873) and rs5750871 (adjusted P  = 0.039, OR = 0.859). In addition, two SNPs turned to be risk factors for SCZ not only in the allele distribution, but also in the genotype distribution: rs132575 (adjusted P  = 0.037) and rs136805 (adjusted P  = 0.037). CONCLUSIONS:Overall, the present study provided evidence that significant association exists between the CACNA1I gene and SCZ in the Uighur Chinese population, subsequent validation of functional analysis and genetic association studies are needed to further extend this study.

KEYWORDS: Schizophrenia, CACNA1I gene, Case-control study, Uighur Chinese

© 2017 biocloud.net版权所有 ICP证：京10042835号