CRISPR-mediated genetic interaction profiling identifies RNA binding proteins controlling metazoan fitness.
Elife. 2017 Jul 18;6
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摘要
, double mutants displayed a severely shortened lifespan. Both genes are required for regulating hundreds of transcripts and isoforms, and both may play a critical role in lifespan extension through insulin signaling. Thus, CRISPR-SGI reveals a rich genetic interaction landscape between RNA binding proteins in maintaining organismal health, and will serve as a paradigm applicable to other biological questions.
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基因功能
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原始数据
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文献解读
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