Role of ARPC2 in Human Gastric Cancer.

Gastric cancer continues to be the second most frequent cause of cancer deaths worldwide. However, the exact molecular mechanisms are still unclear. Further research to find potential targets for therapy is critical and urgent. In this study, we found that promoted cell proliferation and invasion in the human cancer cell line MKN-28 using a cell total number assay, MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide) assay, cell colony formation assay, migration assay, invasion assay, and wound healing assay. For downstream pathways, CTNND1, EZH2, BCL2L2, CDH2, VIM, and EGFR were upregulated by whereas PTEN, BAK, and CDH1 were downregulated by In a clinical study, we examined the expression of duanyu37C2 in 110 cases of normal human gastric tissues and 110 cases of human gastric cancer tissues. duanyu37C2 showed higher expression in gastric cancer tissues than in normal gastric tissues. In the association analysis of 110 gastric cancer tissues, duanyu37C2 showed significant associations with large tumor size, lymph node invasion, and high tumor stage. In addition, patients exhibited lower RFS and OS rates compared with patients. We thus identify that duanyu37C2 plays an aneretic role in human gastric cancer and provided a new target for gastric cancer therapy.

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