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E-cadherin and LGN align epithelial cell divisions with tissue tension independently of cell shape.

Proc. Natl. Acad. Sci. U.S.A.2017 Jul 18;114(29):E5845-E5853. Epub 2017 Jul 03
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摘要

engagement of E-cadherin in an otherwise cohesive cell monolayer, or loss of LGN expression, resulted in randomly oriented cell divisions in the presence of uniaxial stretch. Our findings indicate that E-cadherin plays a key role in sensing polarized tensile forces across the tissue and transducing this information to the spindle orientation machinery to align cell divisions.

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