Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division.

Elife. 2017 Jun 30;6. doi:10.7554/eLife.25014

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摘要

sensory organ precursors (SOPs), the core PCP components initiate the planar polarization of apical-basal determinants, ensuring asymmetric division into daughter cells of different fates. We show that Meru, a RASSF9/RASSF10 homologue, is expressed specifically in SOPs, recruited to the posterior cortex by Frizzled/Dishevelled, and in turn polarizes the apical-basal polarity factor Bazooka (Par3). Thus, Meru belongs to a class of proteins that act cell/tissue-specifically to remodel the core polarity machinery.

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Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division.

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