The formin DAAM is required for coordination of the actin and microtubule cytoskeleton in axonal growth cones.
J. Cell. Sci.2017 Aug 01;130(15):2506-2519. Epub 2017 Jun 12
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摘要
affects growth cone and microtubule morphology, and several aspects of microtubule dynamics; and biochemical and cellular assays revealed a microtubule stabilization activity and binding to the microtubule tip protein EB1. Together, these data suggest that, besides operating as an actin assembly factor, DAAM is involved in linking actin remodeling in filopodia to microtubule stabilization during axonal growth.
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基因功能
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原始数据
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文献解读
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