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DIMT1 overexpression correlates with progression and prognosis in gastric carcinoma.

Hum. Pathol.2017 Dec;70:35-42. Epub 2017 Jun 07
Guangyi Liu 1 , Xudong Peng 1 , Yongqian Cai 2 , Anqi Cheng 1 , Lang Zha 3 , Ziwei Wang 4
Guangyi Liu 1 , Xudong Peng 1 , Yongqian Cai 2 , Anqi Cheng 1 , Lang Zha 3 , Ziwei Wang 4
+ et al

[No authors listed]

Author information
  • 1 Department of Gastrointestinal Surgery, Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China.
  • 2 Department of General Surgery, DaZhou Central Hospital, Dazhou, Sichuan 635000, PR China.
  • 3 Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China.
  • 4 Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China. Electronic address: wangziwei571@sina.com.

摘要


We investigated the expression of dimethyladenosine transferase 1 homolog (DIMT1) in human gastric carcinoma (GC) tissues, pericarcinoma histologically normal tissues, and normal gastric tissues and explored its clinical significance. Immunohistochemistry staining was used to detect the expression of DIMT1, and the findings were compared with clinicopathological features of patients with GC. The result also was ascertained by Western blotting. The Kaplan-Meier method and log-rank test were used to compare the overall survival rate and time in the DIMT1 low-level and high-level expression groups. Immunohistochemical staining indicated that the expression of DIMT1 in GC tissues (65/75; 86.7%) was significantly more common (P<.001) than that in pericarcinoma histologically normal tissues (14/75; 18.7%) and normal gastric tissues (2/12; 16.7%). High expression of DIMT1 correlated closely with differentiation (P=.023), invasion (P=.042), lymph node metastasis (P=.008), distant metastasis (P=.006), and TNM stage (P=.013). Western blotting showed that DIMT1 expression correlated positively with TNM stage and implied that more advanced TNM stage was accompanied by higher expression of DIMT1 (P<.001). Kaplan-Meier survival analysis showed that high DIMT1 expression correlated significantly (P<.001) with a poor prognosis. Our data suggest that DIMT1 is a useful molecular biomarker to predict tumor progression and prognosis in patients with GC.

KEYWORDS: DIMT1, Gastric carcinoma, Prognosis, Progression, Tumor biomarker