Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A.

Arterioscler. Thromb. Vasc. Biol.2017 Aug;37(8):1494-1502. Epub 2017 Jun 08

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OBJECTIVE:To establish the cellular source of plasma factor (F)XIII-A. APPROACH AND RESULTS: mice did not increase plasma FXIII-A levels, suggesting that a limited population of niches exists that support FXIII-A-releasing cells. CONCLUSIONS:This work suggests that resident macrophages maintain plasma FXIII-A and exclude the platelet lineage as a major contributor.

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Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A.

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