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Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart.

Cell Death Dis. 2017 Jun 08;8(6):e2861
Lauren J Maskell 1 , Kashif Qamar 1 , Aram A Babakr 1 , Thomas A Hawkins 2 , Richard J Heads 3 , Vishwanie S Budhram-Mahadeo 1
Lauren J Maskell 1 , Kashif Qamar 1 , Aram A Babakr 1 , Thomas A Hawkins 2 , Richard J Heads 3 , Vishwanie S Budhram-Mahadeo 1
+ et al

[No authors listed]

Author information
  • 1 Medical Molecular Biology Unit, Institute of Cardiovascular Science, University College London, UCL Rayne Building, London, UK.
  • 2 Division of Biosciences, Cell and Developmental Biology, UCL, London, UK.
  • 3 Cardiovascular Division, Faculty of Life Sciences and Medicine, King's College London, London, UK.

摘要

) mutants indicate essential functions with partial redundancy during early embryogenesis. High conservation between mammals and zebrafish (ZF) Brn-3b (87%) or Brn-3a (76%) facilitated use of ZF embryos to study potential roles in developing heart. Double morphant embryos targeted with morpholino oligonucleotides to both TFs develop significant cardiac defects (looping abnormalities and valve defects) suggesting essential roles for Brn-3a and Brn-3b in developing hearts.

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