Quantitative regulation of histone variant H2A.Z during cell cycle by ubiquitin proteasome system and SUMO-targeted ubiquitin ligases.
Biosci. Biotechnol. Biochem.2017 Aug;81(8):1557-1560. doi:10.1080/09168451.2017.1326087. Epub 2017 May 22
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摘要
Quantitative control of histones and histone variants during cell cycle is relevant to their epigenetic functions. We found that the level of yeast histone variant H2A.Z in the G2/M-phase is actively kept low by the ubiquitin proteasome system and SUMO-targeted ubiquitin ligases. Overexpression of H2A.Z induced defects in mitotic progression, suggesting functional importance of this quantitative control.
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基因功能
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原始数据
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文献解读
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