New Role for Interleukin-13 Receptor α1 in Myocardial Homeostasis and Heart Failure.
[No authors listed]
摘要
BACKGROUND:The immune system plays a pivotal role in myocardial homeostasis and response to injury. Interleukins-4 and -13 are anti-inflammatory type-2 cytokines, signaling via the common interleukin-13 receptor α1 chain and the type-2 interleukin-4 receptor. The role of interleukin-13 receptor α1 in the heart is unknown. METHODS AND RESULTS: was associated with reduced collagen deposition under normal and pressure-overload conditions. CONCLUSIONS:The results of our studies in humans and mice indicate, for the first time, a role of interleukin-13 receptor α1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease.
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基因功能
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原始数据
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文献解读
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