Grass Carp Reovirus VP41 Targets Fish MITA To Abrogate the Interferon Response.

J. Virol.2017 Jun 26;91(14)

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MITA is thought to act as an adaptor protein to facilitate the phosphorylation of IRF3 by TBK1 upon viral infection, and it plays a critical role in innate antiviral responses. Here, we report that GCRV VP41 colocalizes with MITA at the ER and reduces MITA phosphorylation by acting as a decoy substrate of TBK1, thus inhibiting IFN production. These findings reveal GCRV's strategy for evading the host IFN response for the first time.

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Grass Carp Reovirus VP41 Targets Fish MITA To Abrogate the Interferon Response.

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