Preliminary Study on the Role of TMEM39A Gene in Multiple Sclerosis.

J. Mol. Neurosci.2017 Jun;62(2):181-187. Epub 2017 Apr 25

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Â =Â 5.429; pÂ =Â 0.0063). In our study, the lower mRNA expression of TMEM39A gene in patients did not correlate with a higher methylation level of the TMEM39A promoter. Moreover, a decreased level of TMEM39A mRNA was associated neither with rs1132200 nor with rs17281647. Additionally, we did not find an association between these two TMEM39A polymorphisms and the risk and progression of multiple sclerosis.Our investigation is the first which indicates that TMEM39A mRNA expression may be associated with the development and/or course of multiple sclerosis.

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Preliminary Study on the Role of TMEM39A Gene in Multiple Sclerosis.

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