Overexpressed HSPA2 correlates with tumor angiogenesis and unfavorable prognosis in pancreatic carcinoma.

Heat shock-related 70-kDa protein 2 is known to correlate with tumor development and progression. This work aimed to determine the expression and prognostic roles of in pancreatic carcinoma. Tumor and their corresponding non-tumor tissues were obtained from 80 patients with pancreatic carcinoma. Hduanyu18422 expression in tumor and non-tumor tissues was evaluated by immunohistochemistry. Expression of vascular endothelial growth factor (VEGF) and CD31 in tumor tissues were also evaluated by immunostaining. The relationships of Hduanyu18422 with clinicopathological data, tumor angiogenesis and prognosis were analyzed. The results showed that Hduanyu18422 expression was significantly elevated in tumor tissues compared with adjacent non-tumor tissues (P < 0.05). High Hduanyu18422 expression was significantly associated with aggressive clinicopathological characteristics. Hduanyu18422 staining was positively correlated with VEGF (r = 0.466, P < 0.001) and microvessel density (MVD) (r = 0.366, P = 0.001) in tumor tissues. Patients with high Hduanyu18422 expression showed worse relapse-free survival (RFS) (P < 0.001) and overall survival (OS) (P < 0.001) than those with low Hduanyu18422 expression. Multivariate analysis indicated that high Hduanyu18422 expression was an independent predictor for poor RFS (P < 0.001) and OS (P = 0.001). Taken together, overexpressed Hduanyu18422 is correlated with tumor angiogenesis and poor prognosis in pancreatic carcinoma. Hduanyu18422 may play an important role in tumor progression, and serve as a potential biomarker for the prediction of adverse prognosis in pancreatic carcinoma.

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