Caffeine ameliorates hyperoxia-induced lung injury by protecting GCH1 function in neonatal rat pups.
Pediatr. Res.2017 Sep;82(3):483-489. Epub 2017 May 24
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摘要
phosphorylated GTP cyclohydrolase 1 (GCH1), and BH4 levels, with improved alveolar structure and angiogenesis in hyperoxia-exposed lungs. Reduced GCH1 levels in hyperoxia were due, in part, to increased degradation by the ubiquitin-proteasome system.ConclusionOur data support the notion that early caffeine treatment can protect immature lungs from hyperoxia-induced damage by improving eNOS activity through increased BH4 bioavailability.
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文献解读
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