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Zebrafish FOXP3 is required for the maintenance of immune tolerance.

Dev. Comp. Immunol.2017 Aug;73:156-162. Epub 2017 Mar 30
Kotaro Sugimoto 1 , Subhra P Hui 1 , Delicia Z Sheng 1 , Maki Nakayama 1 , Kazu Kikuchi 2
Kotaro Sugimoto 1 , Subhra P Hui 1 , Delicia Z Sheng 1 , Maki Nakayama 1 , Kazu Kikuchi 2

[No authors listed]

Author information
  • 1 Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia.
  • 2 Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia; St. Vincent's Clinical School, University of New South Wales, Kensington, NSW 2052, Australia. Electronic address: k.kikuchi@victorchang.edu.au.

摘要


Regulatory T (Treg) cells play a central role in the suppression of excessive immune responses against both self and non-self antigens. The development and function of Treg cells are controlled by a master regulatory gene encoding the forkhead box P3 (FOXP3) protein in mammals. However, little is known regarding the functions of Treg cells and FOXP3 in non-mammalian vertebrates. In this study, we generated mutant zebrafish lacking a functional FOXP3 ortholog, and demonstrated a significant reduction in survival accompanied by a marked increase in inflammatory gene expression, mononuclear cell infiltration, and T cell proliferation in peripheral tissues. Our findings indicate that the zebrafish FOXP3 protein may have an evolutionally conserved role in the control of immune tolerance, illuminating the potential of the zebrafish as a novel model for investigating the development and functions of Treg cells.

KEYWORDS: Autoimmunity, FOXP3, Lymphoproliferation, Regulatory T cells, Zebrafish