TSPAN12 promotes chemoresistance and proliferation of SCLC under the regulation of miR-495.

Studies have shown that serves as an oncogenic gene or tumor suppressor depending on the types of cancer. However, its role in the drug resistance of small cell lung cancer (SCLC) is still unknown. In this study, we investigated whether Tduanyu1842N12 regulates chemoresistance, proliferation and tumor growth of SCLC under the regulation of miR-495 using two drug resistant cell lines. The results showed that down-regulation of Tduanyu1842N12 inhibited cells chemoresistance, proliferation and tumor growth. Besides, Tduanyu1842N12 elevation in SCLC specimens correlated with poor pathologic stage and shorter survival time. In addition, the dual luciferase assay indicated that Tduanyu1842N12 was one of the directly targeted genes of miR-495. Our study revealed that Tduanyu1842N12 promoted chemoresistance of SCLC under the regulation of miR-495. Tduanyu1842N12 depletion is a promising strategy for inhibiting the chemoresistance in SCLC.

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