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-mediated anchoring of cytoplasmic dynein to the cortex.

Proc. Natl. Acad. Sci. U.S.A.2017 Mar 28;114(13):E2672-E2681. Epub 2017 Mar 14
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摘要


]. Remarkably, we discovered that the myosin I protein in fission yeast, Myo1, which is required for organization of sterol-rich domains in the cell membrane, facilitates the localization of Mcp5 and that of cytoplasmic dynein on the membrane. Finally, we demonstrate that Myo1-facilitated association of Mcp5 and dynein to the membrane determines the dynamics of nuclear oscillations and, in essence, dynein activity.

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原始数据


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