Pleiotropic effects of UCP2-UCP3 variability on leucocyte telomere length and glucose homeostasis.

Biogerontology. 2017 Jun;18(3):347-355. Epub 2017 Mar 09

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Â =Â 0.024). In the same samples, AA-rs659366 genotype was found associated with lower haematological levels of Glycosylate Haemoglobyn (pÂ =Â 0.012 and pÂ =Â 0.022, respectively). Furthermore, rs659366-AA at UCP2 and rs15673-TT at UCP3 were correlated to diabetes in a small sub-group of patients. Results here presented suggest that UCP variability has different pleiotropic effects, by affecting both telomere length and glucose homeostasis, likely through an influence on energy metabolism and stress response.

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Pleiotropic effects of UCP2-UCP3 variability on leucocyte telomere length and glucose homeostasis.

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