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Prdx1-encoded peroxiredoxin is important for vascular development in zebrafish.

FEBS Lett.2017 Mar;591(6):889-902. doi:10.1002/1873-3468.12604. Epub 2017 Mar 08
Po-Chun Huang 1 , Chien-Chih Chiu 2 , Hsueh-Wei Chang 3 , Yi-Shan Wang 1 , Hai-Hong Syue 1 , Yi-Chun Song 1 , Zhi-Hong Weng 4 , Ming-Hong Tai 5 , Chang-Yi Wu 6
Po-Chun Huang 1 , Chien-Chih Chiu 2 , Hsueh-Wei Chang 3 , Yi-Shan Wang 1 , Hai-Hong Syue 1 , Yi-Chun Song 1 , Zhi-Hong Weng 4 , Ming-Hong Tai 5 , Chang-Yi Wu 6
+ et al

[No authors listed]

Author information
  • 1 Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.
  • 2 Department of Biotechnology, Kaohsiung Medical University, Taiwan.
  • 3 Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Taiwan.
  • 4 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
  • 5 Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.
  • 6 Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung, Taiwan.

摘要


Genetic signaling and redox homeostasis are required for proper growth of blood vessels. Here, we report a novel function of peroxiredoxin1 (Prdx1) in vascular development in zebrafish. Knockdown of prdx1 impairs the growth of intersegmental vessel and caudal vein plexus (CVP), and reduces the expression of vascular markers, thus suggesting a role for prdx1 in vasculature and indicating that the antioxidant function of prdx1 is important. We found that H2 O2 -treated embryos also have CVP defects and observed synergistic effects when prdx1 knockdown was combined with H2 O2 treatment. Moreover, N-acetyl-cysteine treatment rescues the vascular defects in prdx1 morphants. These results suggest that oxidative stress disturbs vascularization. Furthermore, we show that the regulation of prdx1 is mediated by Notch and BMP signals.

KEYWORDS: peroxiredoxin1, vascular development, zebrafish