Inhibition of Î±9Î±10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.

Proc. Natl. Acad. Sci. U.S.A.2017 Mar 07;114(10):E1825-E1832. Epub 2017 Feb 21

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receptors. A daily s.c. dose of RgIA4 prevented chemotherapy-induced neuropathic pain in rats. In wild-type mice, oxaliplatin treatment produced cold allodynia that could be prevented by RgIA4. Additionally, in Î±9 KO mice, chemotherapy-induced development of cold allodynia was attenuated and the milder, temporary cold allodynia was not relieved by RgIA4. These findings establish blockade of Î±9-containing nAChRs as the basis for the efficacy of RgIA4, and that Î±9-containing nAChRs are a critical target for prevention of chronic cancer chemotherapy-induced neuropathic pain.

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Inhibition of Î±9Î±10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.

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