A Twist2-dependent progenitor cell contributes to adult skeletal muscle.
Nat. Cell Biol.2017 Mar;19(3):202-213. Epub 2017 Feb 20
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摘要
progenitors contribute specifically to type IIb/x myofibres during adulthood and muscle regeneration, and their genetic ablation causes wasting of type IIb myofibres. We show that Tw2 expression maintains progenitor cells in an undifferentiated state that is poised to initiate myogenesis in response to appropriate cues that extinguish Tw2 expression. Tw2-expressing myogenic progenitors represent a previously unrecognized, fibre-type-specific stem cell involved in postnatal muscle growth and regeneration.
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基因功能
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原始数据
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文献解读
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