Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET.
Proc. Natl. Acad. Sci. U.S.A.2017 Mar 07;114(10):E1857-E1865. Epub 2017 Feb 15
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摘要
oocytes were voltage-clamped, and distinct LRET signals were obtained in the resting and slow inactivated states. Intramolecular distances computed from the LRET signals define a geometrical map of Nav1.4 with the bound toxins, and reveal voltage-dependent structural changes related to channel gating.
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基因功能
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原始数据
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文献解读
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