Recruitment of PP1 to the centrosomal scaffold protein CEP192.

Biochem. Biophys. Res. Commun.2017 Mar 18;484(4):864-870. Epub 2017 Feb 08

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Centrosomal protein of 192Â kDa (CEP192) is a scaffolding protein that recruits the mitotic protein kinases Aurora A and PLK1 to the centrosome. Here we demonstrate that CEP192 also recruits the type one protein phosphatase (PP1) via a highly conserved KHVTF docking motif. The threonine of the KHVTF motif is phosphorylated during mitosis and protein kinase inhibition studies suggest this to be a PLK1-dependent process.

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Recruitment of PP1 to the centrosomal scaffold protein CEP192.

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