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Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver.

Cell Rep. 2017 Feb 07;18(6):1499-1511
Gaofeng Li 1 , Tong Ji 2 , Jiang Chen 2 , Yufei Fu 3 , Lidan Hou 1 , Yan Feng 1 , Tingyue Zhang 1 , Tianyu Song 1 , Jie Zhao 2 , Yoko Endo 4 , Hui Lin 2 , Xiujun Cai 5 , Yong Cang 6
Gaofeng Li 1 , Tong Ji 2 , Jiang Chen 2 , Yufei Fu 3 , Lidan Hou 1 , Yan Feng 1 , Tingyue Zhang 1 , Tianyu Song 1 , Jie Zhao 2 , Yoko Endo 4 , Hui Lin 2 , Xiujun Cai 5 , Yong Cang 6
+ et al

[No authors listed]

Author information
  • 1 Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, Zhejiang 310058, China.
  • 2 Department of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
  • 3 Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, Zhejiang 310058, China; Zhejiang Key Laboratory of Gastro-Intestinal Pathophysiology, Zhejiang Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang 310058, China.
  • 4 Signal Transduction Program, Sanford-Burnham Medical Research Institute, La Jolla, CA 92121, USA.
  • 5 Department of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China. Electronic address: cxjzu@hotmail.com.
  • 6 Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, Zhejiang 310058, China. Electronic address: cangyong@zju.edu.cn.

摘要

expression in cells with decreased H3 ubiquitination reinstates the epigenetic gene silencing. Our results suggest that progressive H3 ubiquitination plays an important role in postnatal liver maturation.

KEYWORDS: AFP, CRL4, DCAF8, DDB1, GPC3, H19, H3 ubiquitination, H3K9 methylation, liver maturation

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