α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria.
Nat. Med.2017 Mar;23(3):288-290. Epub 2017 Feb 06
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摘要
Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement α-lipoic acid inhibits cystine stone formation in the Slc3a1(-/-) mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria.
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文献解读
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