Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARÎ±-FGF21 axis.

Toxicology. 2017 Mar 15;379:12-21. Epub 2017 Jan 25

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BACKGROUND & AIMS: mice. METHODS:Mice were fed the Lieber-Decarli ethanol diet to induce alcoholic fatty liver. RESULTS: mice. CONCLUSIONS:These results suggest that CYP2A5 protects against the development of alcoholic fatty liver disease, and the PPARÎ±-FGF21 axis contributes to the protective effects of CYP2A5 on alcoholic fatty liver disease.

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Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARÎ±-FGF21 axis.

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