Suppression of Type I Interferon Signaling by E1A via RuvBL1/Pontin.
J. Virol.2017 Mar 29;91(8)
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摘要
was previously shown to affect interferon signaling in several different ways. Here, we report a novel mechanism reliant on RuvBL1 that E1A uses to prevent activation of interferon-stimulated gene expression following infection or interferon treatment. This adds to the growing knowledge of how viruses are able to inhibit interferon and identifies a novel target used by adenovirus for modulation of the cellular interferon pathway.
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基因功能
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原始数据
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文献解读
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