The immunoglobulin superfamily member CD200R identifies cells involved in type 2 immune responses.
[No authors listed]
摘要
BACKGROUND:The pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5, and IL-13. However, surface receptors that are specifically expressed on type 2 immune cells are less well documented. The aim of this investigation was to identify surface markers associated with type 2 inflammation. METHODS: T cells. Biopsies were obtained for transcriptomic analysis from healthy controls and patients with extrinsic or intrinsic atopic dermatitis (AD) and psoriasis. RESULTS: Th2 cells. Finally, transcriptomic analysis revealed upregulation of CD200R in lesional skin from subjects with an extrinsic AD phenotype compared to healthy skin. CONCLUSION:These results indicate that CD200R expression strongly correlates with Th2 pathology; though, the mechanism is as yet elusive.
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基因功能
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原始数据
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文献解读
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