Creatine Enhances Mitochondrial-Mediated Oligodendrocyte Survival After Demyelinating Injury.
J. Neurosci.2017 Feb 08;37(6):1479-1492. Epub 2017 Jan 09
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摘要
We report that creatine enhances oligodendrocyte mitochondrial function and protects against caspase-dependent oligodendrocyte apoptosis during CNS remyelination. This work has important implications for the development of therapeutic targets for diseases characterized by oligodendrocyte death, including multiple sclerosis.
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文献解读
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