Tbx20 controls the expression of the KCNH2 gene and of hERG channels.

Proc. Natl. Acad. Sci. U.S.A.2017 Jan 17;114(3):E416-E425. Epub 2017 Jan 03

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and increased APD. Our results suggest that Tbx20 controls the expression of hERG channels responsible for the rapid component of the delayed rectifier current. On the contrary, p.R311C Tbx20 specifically disables the Tbx20 protranscriptional activity over KCNH2 Therefore, TBX20 can be considered a KCNH2-modifying gene.

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Tbx20 controls the expression of the KCNH2 gene and of hERG channels.

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