MicroRNA-190b confers radio-sensitivity through negative regulation of Bcl-2 in gastric cancer cells.
Biotechnol. Lett.2017 Apr;39(4):485-490. Epub 2017 Jan 02
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摘要
OBJECTIVES:To determine the role of miR-190b in radio-sensitivity of gastric cancer (GC). RESULTS:In radio-resistant GC cells, down-regulation of miR-190b and up-regulation of Bcl-2 were observed. The protein expression of Bcl-2 was negatively regulated by miR-190b. Overexpression of miR-190b significantly decreased cell viability and enhanced radio-sensitivity of GC cells. Of note, these effects of miR-190b on GC cells radio-sensitivity were abolished by Bcl-2. CONCLUSION:miR-190b confers radio-sensitivity of GC cells, possibly via negative regulation of Bcl-2.
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基因功能
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原始数据
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文献解读
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