Aberrant lung remodeling in a mouse model of surfactant dysregulation induced by modulation of the Abca3 gene.
Ann. Anat.2017 Mar;210:135-146. Epub 2016 Dec 26
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摘要
-rNeo mice were rendered more vulnerable to exogenous injury. Three weeks following intratracheal bleomycin challenge, mAbca3-rNeo mice demonstrated allele-dependent susceptibility to bleomycin including enhanced weight loss, augmented airspace destruction, and increased fibrosis. Removal of the rNeo cassette from mAbca3 alleles resulted in restoration of BAL PL content to wild-type levels and an absence of changes in lung histology up to 32 weeks of age. These results support the importance of surfactant PL homeostasis as a susceptibility factor for both intrinsic and exogenously induced lung injury/remodeling.
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基因功能
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原始数据
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文献解读
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