Adipocyte-specific disruption of mouse Cnot3 causes lipodystrophy.
[No authors listed]
摘要
Lipodystrophy involves a loss of adipose tissue. In mice, disruption of adipose tissue Cnot3, a subunit of the CCR4-NOT deadenylase complex, causes adipose tissue anomalies. In Cnot3(ad-/-) mice, white adipose tissue (WAT) decreases concomitantly with enhanced inflammation, whereas brown adipose tissue increases and contains larger lipid droplets. Cnot3(ad-/-) mice show hyperinsulinemia, hyperglycemia, insulin resistance, and glucose intolerance, and cannot maintain body temperature during cold exposure. Increased expression of inflammatory genes and decreased leptin expression also occur in Cnot3(ad-/-) WAT, achieving levels similar to those in lipodystrophic aP2-nSrebp1c and Pparg(ldi/+) mice; thus, Cnot3(ad-/-) mice exhibit lipodystrophy.
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基因功能
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原始数据
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文献解读
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